HBA-DEALS: accurate and simultaneous identification of differential expression and splicing using hierarchical Bayesian analysis

HBA-DEALS: accurate and simultaneous identification of differential expression and splicing using hierarchical Bayesian analysis

Blog Article

Abstract We present Hierarchical Bayesian Espresso Cups Analysis of Differential Expression and ALternative Splicing (HBA-DEALS), which simultaneously characterizes differential expression and splicing in cohorts.HBA-DEALS attains state of the art or better performance for both expression and splicing and allows genes to be characterized as having differential gene expression, differential alternative splicing, both, or neither.HBA-DEALS analysis of GTEx data demonstrated sets of genes that show predominant DGE or DAST across multiple tissue types.

These sets have pervasive differences WALNUT OIL with respect to gene structure, function, membership in protein complexes, and promoter architecture.